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Garbo C, Locs J, D’Este M, Demazeau G, Mocanu A et al (2020) Advanced Mg, Zn, Sr, Si multi-substituted hydroxyapatites for bone regeneration. Mater Sci Eng C Mater Biol Appl 1(71):653–662. įrasnelli M, Cristofaro F, Sglavo VM, Dirè S et al (2017) Synthesis and characterization of strontium-substituted hydroxyapatite nanoparticles for bone regeneration. Mater Sci Eng C Mater Biol Appl 35:106–114. Ĭox SC, Jamshidi P, Grover LM, Mallick KK (2014) Preparation and characterisation of nanophase Sr Mg, and Zn substituted hydroxyapatite by aqueous precipitation. īegam H, Kundu B, Chanda A, Nandi SK (2017) MG63 osteoblast cell response on Zn doped hydroxyapatite (HAp) with various surface features. Haider A, Haider S, Han SS, Kang I-K (2017) Recent advances in the synthesis, functionalization and biomedical applications of hydroxyapatite: a review. Ĭhadha RK, Singh KL, Sharma C et al (2020) Effect of microwave and conventional processing techniques on mechanical properties of strontium substituted hydroxyapatite. Īzizeh-Mitra Y, Hassane O, Rosa A et al (2014) Physical and biological characteristics of nanohydroxyapatite and bioactive glasses used for bone tissue engineering. The C3 cement (HA-SrMg5%), which was made up of n-HA co-substituted with 5 mol% Sr and 5 mol% Mg, showed exceptional osteoinductive capacity in terms of bone regeneration, indicating that this new bone cement could be a promising material for bone replacement.Ĭacciotti I (2016) Cationic and anionic substitutions in hydroxyapatite, in: Antoniac I (Ed.) Handbook of bioceramics and biocomposites. The ions Ca2 + , Mg2 + , Zn2 + , and Sr2 + appear to cooperate in promoting osteoblast function. These cements had osteoinductive potential, stimulating extracellular matrix (ECM) mineralization and differentiation of MC3T3-E1 cells by increasing ALP and NO production. Cements containing co-substituted n-HAs had excellent cytocompatibility, which improved osteoblast adhesion and cell proliferation. All of the cements stimulated cell proliferation in fibroblasts, endothelial cells, and osteoblasts, were non-cytotoxic, and produced apatite. Cement releases Ca2 + , Mg2 + , Sr2 + , and Zn2 + in concentrations that are suitable for osteoblast proliferation and development. All cements exhibited quite hydrophilic and had high washout resistance. The cements were physicochemically described and tested in vitro using cell cultures. New bone cement type that combines Sr2 + /Mg2 + or Sr2 + /Zn2 + co-substituted nano-hydroxyapatite (n-HAs) with calcium phosphate dibasic and chitosan/gelatin polymers was developed to increase adhesion and cellular response.

Agno3 molar mass